LOCUS       NC_000021               4659 bp    DNA     linear   CON 03-FEB-2014
DEFINITION  Homo sapiens chromosome 21, GRCh38 Primary Assembly.
ACCESSION   NC_000021 REGION: 5012496..5017154 GPC_000001313
VERSION     NC_000021.9  GI:568815577
DBLINK      BioProject: PRJNA168
            Assembly: GCF_000001405.26
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4659)
  CONSRTM   International Human Genome Sequencing Consortium
  TITLE     Finishing the euchromatic sequence of the human genome
  JOURNAL   Nature 431 (7011), 931-945 (2004)
   PUBMED   15496913
REFERENCE   2  (bases 1 to 4659)
  AUTHORS   Lander,E.S., Linton,L.M., Birren,B., Nusbaum,C., Zody,M.C.,
            Baldwin,J., Devon,K., Dewar,K., Doyle,M., FitzHugh,W., Funke,R.,
            Gage,D., Harris,K., Heaford,A., Howland,J., Kann,L., Lehoczky,J.,
            LeVine,R., McEwan,P., McKernan,K., Meldrim,J., Mesirov,J.P.,
            Miranda,C., Morris,W., Naylor,J., Raymond,C., Rosetti,M.,
            Santos,R., Sheridan,A., Sougnez,C., Stange-Thomann,N.,
            Stojanovic,N., Subramanian,A., Wyman,D., Rogers,J., Sulston,J.,
            Ainscough,R., Beck,S., Bentley,D., Burton,J., Clee,C., Carter,N.,
            Coulson,A., Deadman,R., Deloukas,P., Dunham,A., Dunham,I.,
            Durbin,R., French,L., Grafham,D., Gregory,S., Hubbard,T.,
            Humphray,S., Hunt,A., Jones,M., Lloyd,C., McMurray,A., Matthews,L.,
            Mercer,S., Milne,S., Mullikin,J.C., Mungall,A., Plumb,R., Ross,M.,
            Shownkeen,R., Sims,S., Waterston,R.H., Wilson,R.K., Hillier,L.W.,
            McPherson,J.D., Marra,M.A., Mardis,E.R., Fulton,L.A.,
            Chinwalla,A.T., Pepin,K.H., Gish,W.R., Chissoe,S.L., Wendl,M.C.,
            Delehaunty,K.D., Miner,T.L., Delehaunty,A., Kramer,J.B., Cook,L.L.,
            Fulton,R.S., Johnson,D.L., Minx,P.J., Clifton,S.W., Hawkins,T.,
            Branscomb,E., Predki,P., Richardson,P., Wenning,S., Slezak,T.,
            Doggett,N., Cheng,J.F., Olsen,A., Lucas,S., Elkin,C.,
            Uberbacher,E., Frazier,M., Gibbs,R.A., Muzny,D.M., Scherer,S.E.,
            Bouck,J.B., Sodergren,E.J., Worley,K.C., Rives,C.M., Gorrell,J.H.,
            Metzker,M.L., Naylor,S.L., Kucherlapati,R.S., Nelson,D.L.,
            Weinstock,G.M., Sakaki,Y., Fujiyama,A., Hattori,M., Yada,T.,
            Toyoda,A., Itoh,T., Kawagoe,C., Watanabe,H., Totoki,Y., Taylor,T.,
            Weissenbach,J., Heilig,R., Saurin,W., Artiguenave,F., Brottier,P.,
            Bruls,T., Pelletier,E., Robert,C., Wincker,P., Smith,D.R.,
            Doucette-Stamm,L., Rubenfield,M., Weinstock,K., Lee,H.M.,
            Dubois,J., Rosenthal,A., Platzer,M., Nyakatura,G., Taudien,S.,
            Rump,A., Yang,H., Yu,J., Wang,J., Huang,G., Gu,J., Hood,L.,
            Rowen,L., Madan,A., Qin,S., Davis,R.W., Federspiel,N.A.,
            Abola,A.P., Proctor,M.J., Myers,R.M., Schmutz,J., Dickson,M.,
            Grimwood,J., Cox,D.R., Olson,M.V., Kaul,R., Raymond,C., Shimizu,N.,
            Kawasaki,K., Minoshima,S., Evans,G.A., Athanasiou,M., Schultz,R.,
            Roe,B.A., Chen,F., Pan,H., Ramser,J., Lehrach,H., Reinhardt,R.,
            McCombie,W.R., de la Bastide,M., Dedhia,N., Blocker,H.,
            Hornischer,K., Nordsiek,G., Agarwala,R., Aravind,L., Bailey,J.A.,
            Bateman,A., Batzoglou,S., Birney,E., Bork,P., Brown,D.G.,
            Burge,C.B., Cerutti,L., Chen,H.C., Church,D., Clamp,M.,
            Copley,R.R., Doerks,T., Eddy,S.R., Eichler,E.E., Furey,T.S.,
            Galagan,J., Gilbert,J.G., Harmon,C., Hayashizaki,Y., Haussler,D.,
            Hermjakob,H., Hokamp,K., Jang,W., Johnson,L.S., Jones,T.A.,
            Kasif,S., Kaspryzk,A., Kennedy,S., Kent,W.J., Kitts,P.,
            Koonin,E.V., Korf,I., Kulp,D., Lancet,D., Lowe,T.M., McLysaght,A.,
            Mikkelsen,T., Moran,J.V., Mulder,N., Pollara,V.J., Ponting,C.P.,
            Schuler,G., Schultz,J., Slater,G., Smit,A.F., Stupka,E.,
            Szustakowski,J., Thierry-Mieg,D., Thierry-Mieg,J., Wagner,L.,
            Wallis,J., Wheeler,R., Williams,A., Wolf,Y.I., Wolfe,K.H.,
            Yang,S.P., Yeh,R.F., Collins,F., Guyer,M.S., Peterson,J.,
            Felsenfeld,A., Wetterstrand,K.A., Patrinos,A., Morgan,M.J., de
            Jong,P., Catanese,J.J., Osoegawa,K., Shizuya,H., Choi,S. and
            Chen,Y.J.
  CONSRTM   International Human Genome Sequencing Consortium
  TITLE     Initial sequencing and analysis of the human genome
  JOURNAL   Nature 409 (6822), 860-921 (2001)
   PUBMED   11237011
  REMARK    Erratum:[Nature 2001 Aug 2;412(6846):565]
REFERENCE   3  (bases 1 to 4659)
  AUTHORS   Hattori,M., Fujiyama,A., Taylor,T.D., Watanabe,H., Yada,T.,
            Park,H.S., Toyoda,A., Ishii,K., Totoki,Y., Choi,D.K., Groner,Y.,
            Soeda,E., Ohki,M., Takagi,T., Sakaki,Y., Taudien,S.,
            Blechschmidt,K., Polley,A., Menzel,U., Delabar,J., Kumpf,K.,
            Lehmann,R., Patterson,D., Reichwald,K., Rump,A., Schillhabel,M.,
            Schudy,A., Zimmermann,W., Rosenthal,A., Kudoh,J., Schibuya,K.,
            Kawasaki,K., Asakawa,S., Shintani,A., Sasaki,T., Nagamine,K.,
            Mitsuyama,S., Antonarakis,S.E., Minoshima,S., Shimizu,N.,
            Nordsiek,G., Hornischer,K., Brant,P., Scharfe,M., Schon,O.,
            Desario,A., Reichelt,J., Kauer,G., Blocker,H., Ramser,J., Beck,A.,
            Klages,S., Hennig,S., Riesselmann,L., Dagand,E., Haaf,T.,
            Wehrmeyer,S., Borzym,K., Gardiner,K., Nizetic,D., Francis,F.,
            Lehrach,H., Reinhardt,R. and Yaspo,M.L.
  CONSRTM   Chromosome 21 mapping and sequencing consortium
  TITLE     The DNA sequence of human chromosome 21
  JOURNAL   Nature 405 (6784), 311-319 (2000)
   PUBMED   10830953
  REMARK    Erratum:[Nature 2000 Sep 7;407(6800):110]
COMMENT     REFSEQ INFORMATION: The reference sequence is identical to
            CM000683.2.
            On Feb 3, 2014 this sequence version replaced gi:224589813.
            Assembly Name: GRCh38 Primary Assembly
            The DNA sequence is composed of genomic sequence, primarily
            finished clones that were sequenced as part of the Human Genome
            Project. PCR products and WGS shotgun sequence have been added
            where necessary to fill gaps or correct errors. All such additions
            are manually curated by GRC staff. For more information see:
            http://genomereference.org.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI
            Annotation Status           :: Full annotation
            Annotation Version          :: Homo sapiens Annotation Release 106
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 5.2
            Annotation Method           :: Best-placed RefSeq; Gnomon
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4659
                     /organism="Homo sapiens"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
     gene            1..4659
                     /gene="LOC102724184"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Gnomon."
                     /db_xref="GeneID:102724184"
     mRNA            join(1..192,1891..1976,4437..4659)
                     /gene="LOC102724184"
                     /product="DNA (cytosine-5)-methyltransferase 3-like"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Gnomon. Supporting evidence
                     includes similarity to: 2 ESTs, and 91% coverage of the
                     annotated genomic feature by RNAseq alignments, including
                     2 samples with support for all annotated introns"
                     /transcript_id="XM_006723911.1"
                     /db_xref="GI:578836315"
                     /db_xref="GeneID:102724184"
     CDS             join(1..192,1891..1976,4437..4605)
                     /gene="LOC102724184"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Gnomon."
                     /codon_start=1
                     /product="DNA (cytosine-5)-methyltransferase 3-like"
                     /protein_id="XP_006723974.1"
                     /db_xref="GI:578836316"
                     /db_xref="GeneID:102724184"
                     /translation="MTSPPGPPSALPPHPTPGWYLFQFHRLLQYARPKPGSPRPFFWM
                     FVDNLVLNKEDLDVASRFLEMEPVTIPDVHGGSLQNAVRVWSNIPAIRSSRHWALVSE
                     EELSLLAQNKQSSKLAAKWPTKLVKNCFLPLREYFKYFSTELTSSL"
ORIGIN      
        1 atgaccagcc cccccggccc cccctcagcc ctgccccctc accccactcc aggctggtac
       61 ctgttccagt tccaccggct cctgcagtac gcacggccca agccaggcag ccccaggccc
      121 ttcttctgga tgttcgtgga caatctggtg ctgaacaagg aagacctgga cgtcgcatct
      181 cgcttcctgg aggtgcgtgc agggctgcgt gggccgccct ctgacccctg cccacgtgag
      241 ggaggggctt ttctggtgga gctcagtcta caccccaggc tccgggcctg gctccttgcg
      301 gcccctggtt tccaggtgtg tacagggccc aggagagctg ctgtgcagtc cgggcaggga
      361 ctgcggcctg ggacacaaag ccccttcaag gacagcatgg gagggcagtc ccacctcgca
      421 ccactcctgt gctcacagaa cacggcctcg ggggctcacc tcctgcccct gccccctcag
      481 tctccaccca cacacacgca catcacacca cacacacagg tgcacacaca ctgcagtgca
      541 cagtcactgt acacatgcac cacacacagg gacacacttg ccacacacac acaggcacac
      601 tacgtgcaca catactcaca ccacacacat acagcctttt cttcacacgt ctgaatcctg
      661 attgtcagag cagccacttt tggactcagc ggatgggtcc cctctggggc tgatgggccg
      721 ggtgttccag acacttccag ggttggggag ggacggccac acctcagcca caggagacag
      781 gcgtgaggct caggaggggg aatttcctca tgctctcagg ttccatggag gggccacagc
      841 cagcgggggc ccgacccacc gagtgggcag cacctgtggg ccagagcctt tgctgggggt
      901 ccaggtggcg ttgaggttcc tttggtgctg gaatctcgtg gagtggctgg aatgcaaatc
      961 cagctattca gaaggggagc aaacgccatg agctgaaaat cacaaagtct gtgcttttag
     1021 aacaggagac tttgtttctg taaaggggca cagcctgcaa ggtcccgtcc cccaggctgg
     1081 gaagcacggg gcctccacca agaccagagg agccaggagg aggcacttcg aaggggaggg
     1141 gtggctgggg caggagctcc gtgctgaccg ggttggctaa acctgtgcgg caggttatgg
     1201 aggagcggtg aatattcatg aagggggtcc tgctgcgtgc gtactgaaca aaatccgtgg
     1261 aacttacgac ctctgttcac tccggggtgg agtcttatca tgtcagtgtg tcgcaatgag
     1321 gccctaaacc tcagaggtct tctcaggaca caggccctca agcgcacaac ctctgtaaac
     1381 cggccggagc cagtctgtgg tcggggtccc ttatcaggag gaggttcctg aagtcagtct
     1441 cctgcccagt cagagctgtg gtcatggctg tggaacgtgg tcagttggca tctgcaggtg
     1501 gatgagctgc agtcatttga accttgctca tcctcatcgc ggggccagtg cgtgtttagc
     1561 cgctgcagaa aaagcagcag ctgtggcgtg agggcagagt ccgtcctctc agtgtagggc
     1621 acgcggctcg gctcgaccct tgcctggcgc ggcctgaggt cctgtttgta atttgatatc
     1681 ttattgccac agagtctgtt ctgtcagttt aaaataattc atcagcattt ttctccaaag
     1741 gtgattcata agaaaaaagg acgtagggaa cacagtcggg ctagaaagtc cattgaccac
     1801 tcagggccat tggcggctga ggccagtggg cctgtggggg gcgcttaccg tccaggtccc
     1861 ctgacccacg gccgaccctc ccgcccccag atggagccag tcaccatccc agatgtccac
     1921 ggcggatcct tgcagaatgc tgtccgcgtg tggagcaaca tcccagccat aaggaggtat
     1981 ttcctgggca gctgaaagcg ttcagggtca aggggaacat ggacccagaa gcggggttca
     2041 ctgaggaaat ggggtctgtc tagcagagcc aagcccagag cagcctctgc gccccagtgg
     2101 gactgcggtc ggccttcggg gccaccctga gaccctgaag acaccgaagc ctgaggatgc
     2161 ccctttcccc ttggggagct tctccagcac tggctctcag cttctcgggg tccagcccct
     2221 ggacacccat atgcgccatg gcggcctggc cctgaatcgg ctgcagcccc caggctttca
     2281 ttccgtgtgg cctccccacc tcccttgcac acccacaagc tcatgcgtgc tcacactcag
     2341 ccacactcac atgactcact tgcacgctca tccatacgcc tgtgtgctca tgtatgcaca
     2401 cacacacagt cattcccacg gtcacgctca tccacacacc tgtgtgctca tgcatgcaca
     2461 cacagtcatc cccacagtca cgctcatcca cacacccaca tgctccctca gtcacatgct
     2521 cacacaagca cactcacgac taccacctgc atccacacgt tcacatgtgc tcacaatcac
     2581 acaggcacac acgcatcagt ctcacccacc cacacgcttg caccccctgc ggtgcactcc
     2641 tgggctgccc tccccacctt ttggggcctt gaacacatgg cctttcccca cgtgccctct
     2701 ctgcggctaa gcaccccctt ctgctgcccc cacagcctct cccagctgcc cccgcccctc
     2761 aacagccttt ccaggcggcc cagacctcac gacctccagc caaccgccca tccatcccct
     2821 cactcccaca ctcgcctggc gtgcctcgct catacgtgca ttcgtgtgga acgagcgctt
     2881 tctggctcag ctgagtcatg atctcctcct gcctgagagt gagttctgga aacttactcc
     2941 ctctcacctc cccggttcca gcatctccca cgtcaccacc gaggcacgat cctgttgcct
     3001 ggcacctgcc aaggcatggc acctgcaggt cttgctggcc tggcttcccc tggatttgag
     3061 tttgggtggg gctgagccga agcacttttc cagcatgctt tctcttcaga agccctctca
     3121 cctgcatgcc agccttcgca cagcctcccc ctaaccctaa gcctgttccc cgccatgtca
     3181 cttcctggga ggccatgcca ggctctgtgg ggctgggtga gcgggggtga aggtgggggc
     3241 agacccagca acacctgtgt gcattacagg ccatgcctca cctgctgcct ggccccagag
     3301 gctccttggc ccccggaggc tctatgcgtc cacacagcag tgagaacagc gccccatcag
     3361 ggttcttaag tggcaggtgc agccagaccc agggttgctg ctccacaaaa ggcacctccc
     3421 tctgctccag tggccacact tgtggcccct gcaggcttgg gctgtgggct ggcagctgct
     3481 tcttcccagc ccccctttct gagcgaggct ccacagagct cctcacaggg tttcgagggc
     3541 tggatccacc tgagccgtga tcctggggtc acctggttcc cagaaggagg ctggcagttc
     3601 cttcccacag gtttccctcc caggctcctg ggtgtctcaa cagtgacatg agagacaccc
     3661 actcactgaa aggagaaatc cttttgcaga ggtagccacc atcaccccca ggatggttaa
     3721 ggacagtccc cactgcccta gggagggtgc ctgaggagga ggaggaggag ggggacactg
     3781 tatctggcac ttcactcgca gtcttcaccc caaaataaac tgagaaatgt tcctggcctc
     3841 cagtggggtg gctgggagca ggagaggggg tgttggtgcc aagtctgcaa agcccgtctt
     3901 cctcaagggc tcctcacagc aggctggcag gggacctttc ctctcaccac ctgccctcct
     3961 gcacccaggg ctggggctcc cggcacaggc agccccagga acccagggga cggcctttgt
     4021 gatagaattc cctgggaatg ctcgctgact ctgcgagggt ttggccaact tttgcccaga
     4081 gtcctgtcct ttcctctgcg ggggtgctgc ccagggatgg tgacatcctc tagcgatggc
     4141 cctggagctc gctgttcaca cggagtgacc cccagcctgc ttcccagggg accagccccc
     4201 ggccggggga ggcgggaggc aagggagtca tctggtcccc tgttgctcac tccacctcca
     4261 tgagaaaaac tcccagaatc aggcgggggt tccggggggg gggtcttagg cacctgggac
     4321 aactgagagg caggctgttc ccctcgcccc ctcgcagcga ttccttccca gccccatctc
     4381 cggggccacc cagtgggcgc tgcgcttgct cacaaccttc cctcccctcc tctcagcagc
     4441 aggcactggg ctctggtttc ggaagaagaa ttgtccctgc tggcccagaa caagcagagc
     4501 tcgaagctcg cggccaagtg gcccaccaag ctggtgaaga actgctttct ccccctaaga
     4561 gaatatttca agtatttttc aacagaactc acttcctctt tataaatgag tcactatact
     4621 gtgaagaaaa agacttttcc tagaacaaag gcaactttc
//

